Synthesis and structure–activity relationship (SAR) study of 4-azabenzoxazole analogues as H 3 antagonists

…, J Hwa, C Sondey, J Lachowicz, A Palani

文献索引：Shao, Ning; Aslanian, Robert; West Jr., Robert E.; Williams, Shirley M.; Wu, Ren-Long; Hwa, Joyce; Sondey, Christopher; Lachowicz, Jean; Palani, Anandan Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 2075 - 2078

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被引用次数: 3

摘要

The synthesis and SAR of a novel series of 4-azabenzoxazole histamine H3 antagonists is described. Introduction of substituted phenyl, pyridyl and fused heterocyclic groups to the 6- position of the 4-azabenzoxazole core gave a series of compounds with good H3 antagonist activity in both ex vivo and in vivo assays.