Canadian Journal of Chemistry

Hydrogen-deuterium exchange of heteroaromatics in neutral D2O at elevated temperatures

NH Werstiuk, G Timmins

文献索引：Werstiuk, Nick Henry; Timmins, George Canadian Journal of Chemistry, 1981 , vol. 59, p. 1022 - 1024

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被引用次数: 16

摘要

Pyridine (1), 2-methylpyridine (2), 3-methylpyridine (3), 4-methylpyridine (4), and 1, 10- phenanthroline undergo HD exchange in neutral D2O at elevated temperatures (180-300° C). With a suitable choice of temperature and reaction time it is possible to prepare selectively deuterated or perdeuterated substrates in good yield.