New method of preparation of C 2 F 5 Li and its reactions with cyclic imines and lactims: Synthesis of α-pentafluoroethyl proline

…, VG Nenajdenko, GV Röschenthaler

文献索引：Shevchenko, Nikolay E.; Nenajdenko, Valentine G.; Roeschenthaler, Gerd-Volker Journal of Fluorine Chemistry, 2008 , vol. 129, # 5 p. 390 - 396

全文：HTML全文

被引用次数: 30

摘要

Addition of pentafluoroethyllithium to cyclic imines leads to pentafluoroethyl substituted pyrrolidines, piperidines and azepanes while reaction of cyclic lactims gives rise to 2- pentafluoroethyl imines. Oxidative cleavage of 2-furyl-2-pentafluoroethyl pyrrolidine has been found to be an effective method for the preparation of a racemic α-pentafluoroethyl proline.