Tetrahedron letters

Enantioselective Carbolithiation of β-Alkylated Styrene

S Norsikian, I Marek, JF Normant

文献索引：Norsikian, Stephanie; Marek, Ilane; Normant, Jean-F. Tetrahedron Letters, 1997 , vol. 38, # 43 p. 7523 - 7526

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被引用次数: 54

摘要

These puzzling results let us to reconsider our basic idea on the necessary intramolecular chelation since in the carbolithiation reaction of 2, a non favorable seven-membered metalacycle should be formed before hydrolysis. Moreover, recent reports have shown that the carbolithiation reaction of styrene derivative was also possible in good chemical yield without anionic polymerisation[9]. ... So, we decided to investigate the enantioselective carbolithiation of ...