Optimal recognition of neutral endopeptidase and angiotensin-converting enzyme active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors

…, BP Roques, MC Fournie-Zaluski

文献索引：Coric, Pascale; Turcaud, Serge; Meudal, Herve; Roques, Bernard Pierre; Fournie-Zaluski, Marie-Claude Journal of Medicinal Chemistry, 1996 , vol. 39, # 6 p. 1210 - 1219

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被引用次数: 21

摘要

An interesting approach for the treatment of congestive heart failure and chronic hypertension could be to avoid the formation of angiotensin II by inhibiting angiotensin converting enzyme (ACE) and to protect atrial natriuretic factor by blocking neutral endopeptidase 24.11 (NEP). This is supported by recent results obtained with potent dual inhibitors of the two zinc metallopeptidases, such as RB 105, HSCH2CH (CH3) ...