Glycosynthases: mutant glycosidases for oligosaccharide synthesis

LF Mackenzie, Q Wang, RAJ Warren…

文献索引：Mackenzie; Wang; Antony; Warren; Withers Journal of the American Chemical Society, 1998 , vol. 120, # 22 p. 5583 - 5584

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被引用次数: 456

摘要

Efficient methods for the synthesis of oligosaccharides, particularly on the large scale, are unavailable despite the enormous importance of this class of molecules in a range of biological processes1 and their potential as new therapeutics. 2 The synthetic problems reside in the control of both the stereochemistry and the regiochemistry of bond formation, requiring complex protection and activation strategies. While significant advances in ...