Synlett

N-Carbamylamino alcohols as the precursors of oxazolidinones via nitrosation-deamination reaction

…, T Yamazaki, H Ohta, K Shima, K Ohi, S Nishiyama…

文献索引：Suzuki, Masumi; Yamazaki, Takahiro; Ohta, Hiromichi; Shima, Kyoko; Ohi, Katsuhide; Nishiyama, Shigeru; Sugai, Takeshi Synlett, 2000 , # 2 p. 189 - 192

全文：HTML全文

被引用次数: 19

摘要

Abstract: Oxazolidinones were effectively prepared from N-carbamylamino alcohols by treatment with nitrous acid, via N-nitroso compound as the intermediate. A new route to (R)-4- benzyloxazolidinone was developed starting from DL-phenylalanine, utilizing D- hydantoinase-catalyzed enantioselective hydrolysis of 5-benzylhydantoin under the dynamic kinetic resolution conditions, and the subsequent reduction to the precursor for ...