Abstract Herein, we describe the discovery and synthesis of a new series of 1, 2, 4, 7-tetra- substituted indole derivatives as novel AKT inhibitors by optimization of a weak hit methyl 4- (2-aminoethoxy)-1H-indole-2-carboxylate (1). Both representative compounds 6a and 6o exhibited the most potent inhibitory activities against AKT1, with inhibition rates of 72.5% and 78.6%, respectively, at concentrations of 10 nM. In addition, compounds 6a and 6o ...
