前往化源商城

Bioorganic & medicinal chemistry

Synthesis and evaluation of α, α-disubstituted-3-mercaptopropanoic acids as inhibitors for carboxypeptidase A and implications with respect to enzyme inhibitor …

HS Lee, DH Kim

文献索引:Lee, Hyun Soo; Kim, Dong H. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4685 - 4691

全文:HTML全文

被引用次数: 13

摘要

2-Ethyl-2-methyl-3-mercaptopropanoic acid (6) and 2-benzyl-2-methyl-3-mercaptopropanoic acid (7) were synthesized and evaluated as inhibitors for carboxypeptidase A (CPA), a prototypical zinc protease with the expectation that the binding affinities of these inhibitors

 相关合成线路

~82%

~%

~%

~94%

~87%

~%

~%

~%

~%

~83%

~%

~%

~%

~91%

~%

~73%

~%

~%

~62%

~95%

~94%