Tetrahedron: Asymmetry

Chemoenzymatic synthesis of both enantiomers of cispentacin

F Theil, S Ballschuh

文献索引：Theil, Fritz; Ballschuh, Sibylle Tetrahedron Asymmetry, 1996 , vol. 7, # 12 p. 3565 - 3572

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被引用次数: 42

摘要

Based on the lipase-catalysed kinetic resolution of the silyloxyalcohol (1RS, 2SR)-5 by transesterification with vinyl acetate in the presence of lipase from Pseudomonas cepacia a synthesis of both enantiomers of the β-amino acid cispentacin (1R, 2S)-1 and (1S, 2R)-1 using simple functional group interconversions is described.