Tetrahedron letters

Facile synthesis of tert-butyl ester of N-protected amino acids with tert-butyl bromide

P Chevallet, P Garrouste, B Malawska, J Martinez

文献索引：Chevallet, Pierre; Garrouste, Patrick; Malawska, Barbara; Martinez, Jean Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7409 - 7412

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被引用次数: 74

摘要

Abstract A facile synthesis of a wide variety of N-benzyloxycarbonyl-amino acid-tert-butyl ester derivatives under mild conditions is described. N-protected amino acids were esterified with tert-butyl bromide in dimethylacetamide as solvent, in the presence of benzyltriethylammonium chloride (BTEAC) and a large excess of potassium carbonate. Many amino Z-acid-Tert-butyl esters that might be difficult to prepare by other methods ...