Gold-containing indoles as anticancer agents that potentiate the cytotoxic effects of ionizing radiation

…, L Gao, I Lee, T Gray, AJ Berdis

文献索引：Craig, Sandra; Gao, Lei; Lee, Irene; Gray, Thomas; Berdis, Anthony J. Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2437 - 2451

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被引用次数: 22

摘要

This report describes the design and application of several distinct gold-containing indoles as anticancer agents. When used individually, all gold-bearing compounds display cytostatic effects against leukemia and adherent cancer cell lines. However, two gold-bearing indoles show unique behavior by increasing the cytotoxic effects of clinically relevant levels of ionizing radiation. Quantifying the amount of DNA damage demonstrates that each gold– ...