Fast attrition??enhanced deracemization of naproxen by a gradual in situ feed
WL Noorduin, B Kaptein, H Meekes…
文献索引：Noorduin, Wim L.; Kaptein, Bernard; Meekes, Hugo; Enckevort, Willem J. P. van; Kellogg, Richard M.; Vlieg, Elias Angewandte Chemie, International Edition, 2009 , vol. 48, p. 4581 - 4583 Angewandte Chemie, 2009 , vol. 121, p. 4651 - 4653
Abstract Grind and cure: Using the nonsteroidal anti-inflammatory drug naproxen, a novel concept is demonstrated to dramatically enhance the rate of the recently discovered process of deracemization using abrasive grinding. The process relies on a gradual feed of the racemic target material by an in situ conversion.
