Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species

…, H Ibrahim, MS Sajid, MK Gould, A Suksamrarn

文献索引：Changtam, Chatchawan; de Koning, Harry P.; Ibrahim, Hasan; Sajid, M. Sohail; Gould, Matthew K.; Suksamrarn, Apichart European Journal of Medicinal Chemistry, 2010 , vol. 45, # 3 p. 941 - 956

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被引用次数: 87

摘要

The natural curcuminoids curcumin (1), demethoxycurcumin (2) and bisdemethoxycurcumin (3) have been chemically modified to give 46 analogs and 8 pairs of 1: 1 mixture of curcuminoid analogs and these parent curcuminoids and their analogs were assessed against protozoa of the Trypanosoma and Leishmania species. The parent curcuminoids exhibited low antitrypanosomal activity (EC50 for our drug-sensitive Trypanosoma brucei ...