Syntheses of isotopically labeled 4??[1??(3, 5, 5, 8, 8??pentamethyl??5, 6, 7, 8??tetrahydro??2??naphthyl) ethenyl] benzoic acid (LGD1069), a potent retinoid x receptor?? …

…, BA Badea, D Enyeart, EM Berger…

文献索引：Zhang; Badea; Enyeart; Berger; Mais; Boehm Journal of Labelled Compounds and Radiopharmaceuticals, 1995 , vol. 36, # 7 p. 701 - 712

全文：HTML全文

被引用次数: 7

摘要

Abstract LGD1069, 4-[1-(3, 5, 5, 8, 8-pentamethyl-5, 6, 7, 8-tetrahydro-2-naphthyl) ethenyl] benzoic acid, is the first retinoid X receptor (RXR) selective retinoid to enter clinical trials for treatment of dermatological diseases and cancer. In order to examine biological properties such as receptor binding, metabolism and bioavailability,[13 C]-,[14 C]-, and [3 H]-labeled LGD1069 is required. Herein, we describe synthetic methods for preparing isotopically ...