Synthesis of both D-and L-Fmoc-Abu [PO (OCH 2 CH CH 2) 2]-OH for solid phase phosphonopeptide synthesis

G Shapiro, D Buechler, V Ojea, E Pombo-Villar…

文献索引：Shapiro, Gideon; Buechler, Dieter; Ojea, Vicente; Pombo-Villar, Esteban; Ruiz, Maria; Weber, Hans-Peter Tetrahedron Letters, 1993 , vol. 34, # 39 p. 6255 - 6258

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被引用次数: 35

摘要

Abstract The Schöllkopf bislactim ether asymmetric amino acid synthesis was coupled with a subsequent enzyme mediated ester hydrolysis to generate a practical synthesis of both D and L enantiomers of Fmoc-Abu [PO (OCH 2 CH CH 2) 2]-OH (6). With this building block phosphonopeptide isosteres of serine phosphopeptides are accessible by Fmoc-solid phase peptide synthesis.