Tetrahedron Letters

A practical and efficient procedure for reduction of carboxylic acids and their derivatives: use of KBH 4–MgCl 2

YC Qiu, FL Zhang, CN Zhang

文献索引：Qiu, You-Chun; Zhang, Fu-Li; Zhang, Chun-Nian Tetrahedron Letters, 2007 , vol. 48, # 43 p. 7595 - 7598

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被引用次数: 9

摘要

The use of KBH4–MgCl2 to reduce carboxylic acids and their derivatives to the corresponding alcohols or the respective reduced products is described. Methyl (S)-3, 4-O- isopropylidene-3, 4-dihydroxy butanoate 2 used as a reference substrate was reduced with KBH4 and MgCl2 in 1: 1mol ratio to (S)-1, 2-O-isopropylidene-1, 2, 4-butanetriol 1.