Synthesis and bioactivities of novel piperidylpyrimidine derivatives: inhibitors of tumor necrosis factor-alpha production

…, K Iwai, A Kurimoto, S Murata, H Kawakami

文献索引：Fujiwara, Norio; Fujita, Hitoshi; Iwai, Kiyotaka; Kurimoto, Ayumu; Murata, Shinobu; Kawakami, Hajime Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 12 p. 1317 - 1320

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被引用次数: 14

摘要

New piperidylpyrimidine derivatives, including quinazolines, were prepared, and their abilities to inhibit TNF-α production evaluated. Some compounds showed potent inhibitory activity in mouse macrophages stimulated with LPS. The synthesis and structure–activity relationships of these compounds are described.