Novel 4H-1, 3, 4-oxadiazin-5 (6H)-ones with hydrophobic and long alkyl chains: Design, synthesis, and bioactive diversity on inhibition of monoamine oxidase, chitin …
SY Ke, XH Qian, FY Liu, N Wang, Q Yang…
文献索引：Ke, Shao-Yong; Qian, Xu-Hong; Liu, Feng-Yi; Wang, Ni; Yang, Qing; Li, Zhong European Journal of Medicinal Chemistry, 2009 , vol. 44, # 5 p. 2113 - 2121
A new series of nitrogen-containing heterocycles 4H-1, 3, 4-oxadiazin-5 (6H)-ones derivatives with hydrophobic and long chains were designed and synthesized by direct cyclization reaction of N′-alkylation substituted aroylhydrazines with chloroacetyl chloride. The preliminary assays showed that some of the compounds displayed moderate to good inhibitory activities toward monoamine oxidase (MAO) at the concentration of 10− 5–10− ...
