Process development and large-scale synthesis of a c-met kinase inhibitor

GW Stewart, KMJ Brands, SE Brewer…

文献索引：Organic Process Research and Development, , vol. 14, # 4 p. 849 - 858

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被引用次数: 13

摘要

... Organic Process Research & Development. ... Core 2 The tricyclic core 2 was prepared using a modified version of the Medicinal Chemistry procedure. ... synthesized from vinamidinium salt 19 (Scheme 5) using chemistry previously reported by Merck Process Research.(10) Thus ...