'Through??space'hydrogen–fluorine, carbon??fluorine and fluorine–fluorine spin–spin coupling in 2??phenyl??3??alkyl??4, 5, 6, 7??tetrahydroindazoles
…, RN Henrie, GA Meier, RW Creekmore…
文献索引：Lyga, John W.; Henrie, Robert N.; Meier, Gary A.; Creekmore, R. William; Patera, Russell M. Magnetic Resonance in Chemistry, 1993 , vol. 31, # 4 p. 323 - 328
Abstract 1 H, 13 C and 19 F NMR experiments for a series of 3-alkyl-2-phenyl-4, 5, 6, 7- tetrahydroindazoles revealed a six-bond through-space coupling between the ortho-fluorine and the hydrogen or fluorine atom of the position 3-alkyl group. This was further supported by NOE experiments. Molecular mechanics calculations on a representative structure indicated that several low energy conformers met the fluorine-carbon distance constraint ...
