Fluorinated ΔF508-CFTR correctors and potentiators for PET imaging

…, DM Solano, PW Phuan, AS Verkman, MJ Kurth

文献索引：Davison, Holly R.; Solano, Danielle M.; Phuan, Puay-Wah; Verkman; Kurth, Mark J. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1602 - 1605

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摘要

19F-modified bithiazole correctors and phenylglycine potentiators of the ΔF508-CFTR chloride channel were synthesized and their function assayed in cells expressing human ΔF508-CFTR and a halide-sensitive fluorescent protein. Fluorine was incorporated into each scaffold using prosthetic groups for future biodistribution imaging studies using positron emission tomography (PET). The ΔF508-CFTR corrector and potentiator potencies of the ...