Tetrahalogenomethanes: simple reagents for the synthesis of monohalogenated and mixed dihalogenated aromatic heterocycles via metal–halogen exchange from …
…, E Del Vecchio, L Forlani, PE Todesco
文献索引：Boga, Carla; Del Vecchio, Erminia; Forlani, Luciano; Todesco, Paolo Edgardo Journal of Organometallic Chemistry, 2000 , vol. 601, # 2 p. 233 - 236
Tetrabromo-or tetrachloromethane and 2-lithio derivatives of aromatic heterocycles rapidly produce the corresponding 2-bromo or 2-chloro derivatives in high yields through a metal– halogen exchange mechanism. This kind of reaction was also used to obtain, in good yields, 5-bromo-2-chlorothiazole and 5-bromo-2-chloro-N-methylimidazole.
