Construction of a family of biphenyl combinatorial libraries: structure-activity studies utilizing libraries of mixtures

…, T Nechuta, A Bronnenkant, A Wu, L Armstrong…

文献索引：Neustadt, Bernard R.; Smith, Elizabeth M.; Lindo, Neil; Nechuta, Terry; Bronnenkant, Alan; Wu, Arthur; Armstrong, Lydia; Kumar, Chandra Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 17 p. 2395 - 2398

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被引用次数: 29

摘要

A set of biphenyl aminoacid building blocks has been synthesized. These were used to construct partially-peptidic combinatorial libraries as equimolar multi-component samples. Activity of members of this library as vitronectin receptor antagonists is described, together with SAR studies of the most active members. These studies illustrate several important features of combinatorial libraries.