Asymmetric hydrogenation of quinoxalines catalyzed by iridium/PipPhos
N Mršić, T Jerphagnon, AJ Minnaard…
文献索引：Mrsic, Natasa; Jerphagnon, Thomas; Minnaard, Adriaan J.; Feringa, Ben L.; De Vries, Johannes G. Advanced Synthesis and Catalysis, 2009 , vol. 351, # 16 p. 2549 - 2552
Abstract A catalyst made in situ from the (cyclooctadiene) iridium chloride dimer,[Ir (COD) Cl] 2, and the monodentate phosphoramidite ligand (S)-PipPhos was used in the enantioselective hydrogenation of 2-and 2, 6-substituted quinoxalines. In the presence of piperidine hydrochloride as additive full conversions and enantioselectivities of up to 96% are obtained.
