Novel 3-pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors

…, DL Donnelly-Roberts, DJ Anderson…

文献索引：Abreo, Melwyn A.; Lin, Nan-Horng; Garvey, David S.; Gunn, David E.; Hettinger, Ann-Marie; Wasicak, James T.; Pavlik, Patricia A.; Martin, Yvonne C.; Donnelly-Roberts, Diana L.; Anderson, David J.; Sullivan, James P.; Williams, Michael; Arneric, Stephen P.; Holladay, Mark W. Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 817 - 825

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被引用次数: 255

摘要

Recent evidence indicating the therapeutic potential of cholinergic channel modulators for the treatment of central nervous system (CNS) disorders as well as the diversity of brain neuronal nicotinic acetylcholine receptors (nAChRs) have suggested an opportunity to develop subtype-selective nAChR ligands for the treatment of specific CNS disorders with reduced side effect liabilities. We report a novel series of 3-pyridyl ether compounds which ...