Design and synthesis of 3-[3-(substituted phenyl)-4-piperidin-1-ylmethyl/-4-morpholin-4-ylmethyl-4, 5-dihydro-isoxazol-5-yl]-1H-indoles as potent anti-inflammatory …
Abstract The synthesis of new indole derivatives bearing isoxazoline moiety (3a–d and 4a– d) has been described. IR, 1 H NMR, and mass spectral data supported the structures of synthesized compounds. The compounds were tested in vivo for their anti-inflammatory activity by carrageenin-induced rat paw edema method. The compounds that showed good anti-inflammatory activity were screened for their ulcerogenic and lipid peroxidation ...
