Abstract The dual recognition properties of pyrrolidino DNA species as parallel triplex- forming oligonucleotides were previously found to be strongly dependent upon the nature of the pyrimidine bases. In the structure–activity study presented here we were able to exclude this differential binding being due to their 2-oxo function. We had previously reported on the incorporation of pyrrolidino C-nucleosides into triplex-forming 2′-deoxyoligonucleotides ( ...
