Abstract Enantiomerically pure trans-2-aminocyclohexanecarboxylic acid is an important building block for helical β-peptides. We report here that this amino acid can be obtained from trans-cyclohexane-1, 2-dicarboxylic acid in good yield by a simple one-pot procedure comprising cyclization to the anhydride, amide formation with ammonia, and a subsequent Hofmann-type degradation with phenyliodine (III) bis (trifluoroacetate)(PIFA) as the ...
[Raguse, Tami L.; Porter, Emilie A.; Weisblum, Bernard; Gellman, Samuel H. Journal of the American Chemical Society, 2002 , vol. 124, # 43 p. 12774 - 12785]
