A series of imidazolyl-containing bisphosphonates with abundant hydrogen-bonding interactions: syntheses, structures, and bone-binding affinity

…, J Lin, L Wang, W Cheng, Y Cao, X Liu, S Luo

文献索引：Qiu, Ling; Lin, Jianguo; Wang, Liqing; Cheng, Wen; Cao, Yang; Liu, Xuewen; Luo, Shineng Australian Journal of Chemistry, 2014 , vol. 67, # 2 p. 192 - 205

全文：HTML全文

被引用次数: 6

摘要

Abstract A series of novel bisphosphonates (BPs) were designed and synthesised as longer- chain analogues of the clinically widely used BP–zoledronate (ZL). They were characterised by mass spectrometry, infrared spectroscopy, NMR spectroscopy, and single-crystal X-ray diffraction. All the crystals are zwitterions with one of the phosphonate oxygen atoms deprotonated and the hydrogen atom transferred to the nitrogen of the imidazole ring. A lot ...