Inhibition of copper-dependent amine oxidases by some hydrazides of pyrrol-1-ylbenzoic and pyrrol-1-ylphenylacetic acids

M Artico, F Corelli, S Massa, G Stefancich…

文献索引：Artico, Marino; Corelli, Federico; Massa, Silvio; Stefancich, Giorgio; Avigliano, Luciana; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 802 - 806

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被引用次数: 21

摘要

Some hydrazides of pyrrol-1-ylbenzoic and pyrrol-1-ylphenylacetic acids were prepared, and their effect on cop-per-dependent amine oxidases (Cu-AOs) and FAD monoamine oxidases (MAOs) activities was tested. The compounds were not substrates for Cu-A0 enzymes but acted as noncompetitive inhibitors. Hydrazides of pyrrol-1-ylphenylacetic acids were highly specific for plasma amine oxidase (Ki= 0.5-1 yM). In contrast, all the ...