Asymmetrical 2, 6-bis (benzylidene) cyclohexanones: Synthesis, cytotoxic activity and QSAR study

…, E Alipour, S Emami, AF Atash, M Jafari-Zavareh…

文献索引：Nakhjiri, Maryam; Safavi, Maliheh; Alipour, Eskandar; Emami, Saeed; Atash, Amir Farzin; Jafari-Zavareh, Mona; Ardestani, Sussan K.; Khoshneviszadeh, Mehdi; Foroumadi, Alireza; Shafiee, Abbas European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 113 - 123

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被引用次数: 23

摘要

In order to develop novel anti-cancer agents, a series of asymmetrical 2, 6-bis (benzylidene) cyclohexanone derivatives containing nitrobenzylidene moiety were synthesized and their cytotoxic activity were determined in vitro against MDA-MB 231, MCF-7 and SK-N-MC cell lines using MTT assay. Among the tested compounds, the highest activity against MDA-MB 231 cells was achieved by 2-(3-bromo-5-methoxy-4-propoxybenzylidene)-6-(2- ...