The Design and Synthesis of 1, 4-Substituted Piperazine Derivatives as Triple Reuptake Inhibitors

…, YH Han, CM Song, HG Hahn

文献索引：Han, Minsoo; Han, Younghue; Song, Chiman; Hahn, Hoh-Gyu Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 8 p. 2597 - 2602

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被引用次数: 6

摘要

Abstract Novel 1, 4-substituted piperazine derivatives 5, Series A and B were designed by fragment analysis and molecular modification of 4 selected piperazine-containing compounds which possess antidepressant activity. We synthesized new 39 analogues of Series A and 10 compounds of Series B, respectively. The antidepressant screening against DA, NE, and serotonin neurotransmitter uptake inhibition was carried out using the ...