Regioselective synthesis and antimicrobial studies of ester linked 1, 4-disubstituted 1, 2, 3-bistriazoles

K Lal, A Kumar, MS Pavan, CP Kaushik

文献索引：Lal, Kashmiri; Kumar, Ashwani; Pavan; Kaushik Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 13 p. 4353 - 4357

全文：HTML全文

被引用次数: 12

摘要

A series of 1, 4-disubstituted 1, 2, 3-bistriazoles was synthesized via click chemistry by cycloaddition of various bisalkynes with benzyl/2-phenylethyl azide. Synthesized triazoles were characterized by IR, 1H NMR, 13C NMR and mass spectral techniques. All the compounds were evaluated for antibacterial/antifungal activities and found to possess moderate to good antimicrobial activities. Further the docking study for the most active ...