Archiv der Pharmazie

Synthesis and biological evaluation of some novel fused pyrazolopyrimidines as potential anticancer and antimicrobial agents

HA Abd El Razik, AE Abdel Wahab

文献索引：Abd El Razik, Heba A.; Abdel Wahab, Abeer E. Archiv der Pharmazie, 2011 , vol. 344, # 3 p. 184 - 196

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被引用次数: 9

摘要

Abstract Synthesis and evaluation of anticancer and antimicrobial activity of some novel pyrazolopyrimidines and fused pyrazolopyrimidines are reported. Twelve analogs were selected to be evaluated for their in vitro anticancer potential against a panel of three human tumor cell lines: hepatocellular carcinoma HepG2, cervical carcinoma HelaS3 and colon carcinoma CaCo. The obtained data revealed that eight compounds namely; 6b, 6d, 7c, ...