Total synthesis of (-)-grayanotoxin III

T Kan, S Hosokawa, S Nara, M Oikawa…

文献索引：Kan, Toshiyuki; Hosokawa, Seijiro; Nara, Shinji; Oikawa, Masato; Ito, Shinya; et al. Journal of Organic Chemistry, 1994 , vol. 59, # 19 p. 5532 - 5534

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被引用次数: 71

摘要

Summary: Total synthesis of (-)-grayanotoxin I11 (31, a unique tetracyclic diterpene isolated from the leaves of various plants of the family Ericuceae, has been success- fully accomplished featuring the highly stereoselective cyclization reactions induced by SmI2. ... Grayanotoxins such as grayanotoxin I-IV (1-4) are a unique class of toxic diterpenoids that occur in leaves of various plants belonging to the family Ericuceue.' Be- cause these toxins exert their ...