Tetrahedron letters

A convenient method for the preparation of acylsulfonamide libraries

CF Sturino, M Labelle

文献索引：Sturino, Claudio F.; Labelle, Marc Tetrahedron Letters, 1998 , vol. 39, # 33 p. 5891 - 5894

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被引用次数: 45

摘要

The preparation of an acylsulfonamide library is described using resin bound EDC (1-(3- dimethylaminopropyl)-3-ethylcarbodiimide). A polymer supported sulfonic acid (A-15) is used as a scavenger to remove dimethylaminopyridine and purification only involves filtration of the reaction mixture. This method provides the acylsulfonamides products in good yields and purity.