The Journal of Organic Chemistry

An efficient total synthesis of desferrioxamine B

RJ Bergeron, JJ Pegram

文献索引：Bergeron, Raymond J.; Pegram, Joseph J. Journal of Organic Chemistry, 1988 , vol. 53, # 14 p. 3131 - 3134

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被引用次数: 30

摘要

The total syntheses of the microbial iron chelator desferrioxamine B hydrochloride and some analogues are described. The synthetic scheme is highly flexible, providing access to dihydroxamate, trihydroxamate, tetrahydroxamate, and higher homologues of desferrioxamine. The procedure also allows for access to primary amino nitrogen functionalized desferrioxamines. The scheme is predicated on the generation of the key ...