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Synthesis of 3-Trifluoromethyltyrosine1

R Filler, BT Khan, CW McMullen

文献索引:Filler,R. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 4660 - 4662

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被引用次数: 21

摘要

TI7e have now found that the ether linkage is smoothly cleaved without h) drolysis of the CF3 group when compound I11 is heated at 210'for twenty minutes with fused pyridine hydrochloride. In this way, compound I1 was readily prepared in 75% yield. If the reaction time was increased or the temperature raised above 210, the desired product was accompained by increasing amounts of IV. In contrast to these selective conditions, the ...