Synthesis and pharmacological evaluation of 2 (3H)-furanones and 2 (3H)-pyrrolones, combining analgesic and anti-inflammatory properties with reduced …
MM Alam, A Husain, SM Hasan, T Anwer
文献索引：Alam; Husain, Asif; Hasan; Suruchi; Anwer European Journal of Medicinal Chemistry, 2009 , vol. 44, # 6 p. 2636 - 2642
A series of 3-arylidene-5-(4-chloro-phenyl)-2 (3H)-furanones (2–13) and their nitrogen analogues 1-benzylpyrrolones (14–18) were synthesized. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation actions. Some of the newly synthesized compounds showed good anti-inflammatory and analgesic activities with low GI toxicity and reduced lipid peroxidation. The biological activity was found to ...
