Palladium-catalyzed cyclization/carboalkoxylation of alkenyl indoles

C Liu, RA Widenhoefer

文献索引：Liu, Cong; Widenhoefer, Ross A. Journal of the American Chemical Society, 2004 , vol. 126, # 33 p. 10250 - 10251

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被引用次数: 113

摘要

Reaction of 1-methyl-2-(4-pentenyl) indole with a catalytic amount of PdCl2 (CH3CN) 2 (5 mol%) and a stoichiometric amount of CuCl2 (3 equiv) in methanol under CO (1 atm) at room temperature for 30 min led to cyclization/carboalkoxylation to form the corresponding tetrahydrocarbazole in 83% isolated yield as a single regioisomer. Palladium-catalyzed cyclization/carboalkoxylation of 2-(4-pentenyl) indoles tolerated substitution along the ...