Efficient inhibition of human leukocyte elastase and cathepsin G by saccharin derivatives

WC Groutas, N Houser-Archield…

文献索引：Journal of Medicinal Chemistry, , vol. 36, # 21 p. 3178 - 3181

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被引用次数: 49

摘要

... Subsequent trapping by an active site nucleophile (His-57) was anticipated to lead to irreversible inactivation of the enzyme. 0 1993 American Chemical Society ... Table I. Phyeical Constants and Spectral Data of Inhibitors Journal of Medicinal Chemistry, 1993, Vol. ...