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Highly Efficient RhI??Catalyzed Asymmetric Hydrogenation of β??Amino Acrylonitriles

…, G Hou, T Sun, X Zhang, W Li, J Wang…

文献索引:Ma, Miaofeng; Hou, Guohua; Sun, Tian; Zhang, Xiaowei; Li, Wei; Wang, Junru; Zhang, Xumu Chemistry - A European Journal, 2010 , vol. 16, # 18 p. 5301 - 5304

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被引用次数: 13

摘要

Enantiomerically pure β-amino nitriles and their derivatives are important intermediates in organic synthesis and pharmaceutical chemistry. The nitrile group is one of the most versatile functional groups in organic chemistry and can be readily transformed into a variety of valuable functionalities,[1] including carboxyl; aldehyde; and amino groups, and, hence, β- amino nitriles enable facile approaches to β-amino acids, aldehydes, and 1, 3-diamines. ...