Novel diphenylalkyl piperazine derivatives with dual calcium antagonistic and antioxidative activities

…, T Masuda, K Yamada, N Kubota, N Kawakatsu…

文献索引：Kimura, Makoto; Masuda, Tomoko; Yamada, Koji; Kubota, Nobuo; Kawakatsu, Nobuyuki; Mitani, Masaki; Kishii, Kenichi; Inazu, Masato; Namiki, Takayuki Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 15 p. 1947 - 1950

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被引用次数: 20

摘要

Two types of novel diphenylalkyl piperazine derivatives containing the thio or aminopropanol moiety substituted by phenyl or benzyl group were synthesized, and evaluated for their calcium antagonistic and antioxidative activities. These compounds showed apparent inhibitions against KCl-induced contractions in isolated rat aorta. Among them, phenylamino compound 9 and benzylamino compound 13 also possessed potent ...