Angewandte Chemie International Edition

Triblock Peptide and Peptide Thioester Synthesis With Reactivity??Differentiated Sulfonamides and Peptidyl Thioacids

D Crich, I Sharma

文献索引：Crich, David; Sharma, Indrajeet Angewandte Chemie, International Edition, 2009 , vol. 48, # 41 p. 7591 - 7594

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被引用次数: 37

摘要

With the construction of peptides by solid-phase peptide synthesis limited, for practical reasons, to chains of around fifty residues,[1] the development of methods for the assembly of peptide blocks into longer sequences is of importance. Kent s concept [2] of native chemical ligation was a major advance in this area, and has been considerably extended and optimized since its introduction in 1994.[1, 3] A significant number of these ...