Dehydrooligopeptides. I. The facile coupling of. ALPHA.-amino acids with. ALPHA.-dehydroamino acids to dehydrodipeptides.

Y Yonezawa, C Shin, Y Ono, J Yoshimura

文献索引：Yonezawa; Shin; Ono; Yoshimura Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 10 p. 2905 - 2909

全文：HTML全文

被引用次数: 34

摘要

N-Cbz-or N-Tos-α-dehydroamino acid (DHA) and its ester were prepared by the condensation of 2-oxo carboxylic acid or ester with benzyl carbamate or p- toluenesulfonamide. Subsequently, the N-protected DHA and its N-free ester thus obtained were coupled with several L-α-amino acid esters and N-protected (Boc or Cbz)-L-α-amino acid respectively by the usual peptide synthetic methods to give a number of different ...