Design and synthesis of novel imidazo [1, 2-a] quinoxalines as PDE4 inhibitors

…, G Subra, JR Fabreguettes, A Ovens, M Carraz…

文献索引：Deleuze-Masquefa, Carine; Gerebtzoff, Gregori; Subra, Guy; Fabreguettes, Jean-Roch; Ovens, Annabel; Carraz, Maelle; Strub, Marie-Paule; Bompart, Jacques; George, Pascal; Bonnet, Pierre-Antoine Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 1129 - 1139

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被引用次数: 21

摘要

New imidazo [1, 2-a] quinoxaline derivatives have been synthesised by condensation of an appropriate α-aminoalcohol with a quinoxaline followed by intramolecular cyclisation and nucleophilic substitutions. Their phosphodiesterase inhibitory activities have been assessed on a preparation of the PDE4 isoform purified from a human alveolar epithelial cell line (A549). These studies showed potent inhibitory properties that emphasize the importance ...