o-Nitrophenyl esters of benzyloxycarbonylamino acids and their application in the synthesis of peptide chains by the in situ technique

M Bodanszky, M Kondo, CY Lin…

文献索引：Bodanszky,M. et al. Journal of Organic Chemistry, 1974 , vol. 39, # 4 p. 444 - 447

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被引用次数: 32

摘要

Synthesis of S-benzyl-~-cysteinyl-~-tyrosyl-~-isoleucyl-~-glutaminyl-~-asparaginyl-S-benzyl- ~-cysteinyl-~-pro-lyl-L-leucylglycinamide (S, S'-dibenzyloxytoceine) is described. The partially protected tetrapeptide derivative, S-benzyl-L-cysteinyl-L-prolyl-r.-leucylglycinamide, was acylated with the o-nitrophenyl ester of benzyloxycarbonyl-L-asparagine and the chain was lengthened in the same manner, with o-nitrophenyl esters of ...