Abstract An efficient synthesis of an array of quinazolin-4 (3H)-ones from anthranilic acid, ortho esters (or formic acid) and amines using Yb (OTf) 3 in one-pot under solvent-free conditions is described. Compared with the classical reaction conditions, this new synthetic method has the advantage of excellent yields (75-99%), shorter reaction time (few minutes) and reusability of the catalyst.
