Synthesis

Yb (OTf) 3-catalyzed one-pot synthesis of quinazolin-4 (3H)-ones from anthranilic acid, amines and ortho esters (or formic acid) in solvent-free conditions

L Wang, J Xia, F Qin, C Qian, J Sun

文献索引：Wang, Limin; Xia, Jianjun; Qin, Fang; Qian, Changtao; Sun, Jie Synthesis, 2003 , # 8 p. 1241 - 1247

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被引用次数: 86

摘要

Abstract An efficient synthesis of an array of quinazolin-4 (3H)-ones from anthranilic acid, ortho esters (or formic acid) and amines using Yb (OTf) 3 in one-pot under solvent-free conditions is described. Compared with the classical reaction conditions, this new synthetic method has the advantage of excellent yields (75-99%), shorter reaction time (few minutes) and reusability of the catalyst.