Design, synthesis, and in vitro gene delivery efficacies of novel cholesterol-based gemini cationic lipids and their serum compatibility: a structure-activity investigation

A Bajaj, P Kondiah, S Bhattacharya

文献索引：Bhattacharya; Krishnan-Ghosh Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001 , vol. 40, # 10 p. 891 - 894

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被引用次数: 91

摘要

Five cholesterol-based gemini cationic lipids, which differ in the length of the spacer [-(CH2) n-] chain between the head groups, have been synthesized. These lipids are useful as nonviral gene delivery agents, and all cholesterol-based gemini lipids (2a-2e) are better